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An old 2003 image of the Mississippi River in New Madrid Missouri home of the New Madrid Fault Line. The Mississippi Valley-"Whole Lotta Shakin' Goin' On" In the winter of 1811-12, the central Mississippi Valley was struck by three of the most powerful earthquakes in U.S. history. Even today, this region has more earthquakes than any other part of the United States east of the Rocky Mountains. Government agencies, universities, and private organizations are working to increase awareness of the earthquake threat and to reduce loss of life and property in future shocks.